SVF Cellular Rejuvenation

Step 1: Specialized Consultation and Skin Assessment

In the first session, a dermatologist or aesthetic specialist evaluates your skin type, biological age, aging patterns, current medications, and lifestyle to determine if you are a suitable candidate for SVF. At this stage, skin imaging is usually performed using analyzer devices to assess subcutaneous fat, wrinkle depth, and collagen density. If you have a history of medical conditions or surgery, necessary medical coordination is done at this stage.

Step 2: Preparation and Selection of Fat Harvesting Area

Areas such as abdomen, flanks, or thighs are usually ideal for fat harvesting, as the fat in these regions is soft and rich in stem cells. After disinfection and local anesthesia, the doctor harvests a small amount of fat (about 20–40 mL) using a very fine cannula. This amount equals a few teaspoons and does not alter the body’s shape. The entire harvesting process takes about 15–20 minutes.

Step 3: Isolation of Active Cells in a Closed System

The harvested fat is immediately transferred to the clinic’s sterile laboratory and placed in a specialized centrifuge. In this device, controlled spinning separates the different components of the fat. The middle layer, known as the stromal-vascular fraction (SVF), contains stem cells, pericytes, and growth factors. In the latest protocols at Dr. Fatouhi’s clinic, nano-filters and a closed washing system are used to prevent any contamination or exposure to air. At the end of this stage, a clear, golden-colored solution containing millions of live, active cells is obtained.

Step 4: Cellular Injection into the Target Area

After preparing the cell solution, the doctor uses very fine syringes (Micro-Cannula) to mark the injection sites. Injection depth varies depending on the treatment area:

• Face and neck: injection into the mid-dermal layer to stimulate collagen production
• Back of hands or décolletage: more superficial injection to improve texture and firmness
• Scalp: precise injection between follicles to stimulate hair growth
• Female genital area: delicate injection to restore tissue structure

This stage is generally painless and performed under local anesthesia. The total injection time is between 30–60 minutes. After completion, the patient can return home immediately.

Step 5: Recovery and Initial Care

After injection, the skin may appear slightly red or swollen, which typically subsides within 24–48 hours. The doctor provides a healing cream and home care instructions (detailed in Chapter 7). Cold compresses and avoiding excessive heat during the first days are sufficient.

Step 6: Follow-Up and Specialized Check-Up

A follow-up session is usually scheduled between the third and fourth week to assess tissue improvement, skin hydration, and radiance. At this stage, the doctor can decide if a booster or combination with complementary treatments such as mesotherapy, nano-fat, or non-invasive RF is necessary. The goal is to ensure the reconstruction process is on track and to document before-and-after results.

Step 7: Long-Term Skin Maintenance

SVF treatment results typically peak between the second and third months and remain stable for up to two years. However, performing an annual light maintenance injection or combining with antioxidant mesotherapy can enhance longevity and radiance. The doctor designs a personalized maintenance plan based on your age, skin type, and lifestyle.

⏳ Timeline of SVF Results — From Injection Day to Two Years

Unlike temporary methods such as fillers or Botox, which show immediate results but fade in months, SVF (Stromal Vascular Fraction) works based on cellular regeneration. Therefore, results appear gradually, naturally, and sustainably. Each time frame represents a stage of internal skin restoration — from stem cell activation to stabilization of new collagen networks and blood vessels.

🔹 Week 1 — Initiation of Cellular-Level Regeneration

In the first few days post-injection, the skin may be slightly swollen and red. During this time, internal processes begin: stem cells and pericytes assess the tissue environment and migrate toward areas needing repair (Homing). Controlled inflammation acts as a signal to trigger repair. The skin’s appearance does not change dramatically yet, but under the microscope, the regeneration cycle is active.

🔹 Weeks 2–4 — Brighter Color and Increased Softness

From the second week onward, most patients notice softer and more supple skin. Skin tone becomes more uniform, and dryness decreases. Endothelial cells form new blood vessels (neovascularization), improving capillary blood flow and oxygen delivery. Simultaneously, fibroblasts in the dermis start synthesizing collagen types I and III.

🔹 Months 2–3 — Peak Regeneration and Skin Firmness

This period is the golden phase of SVF treatment. The skin is reconstructed internally, dermal thickness increases, and new collagen strengthens tissue structure. Fine lines around the eyes and mouth diminish, and overall skin texture improves naturally. Complexion becomes more even and radiant; many patients describe this phase as: “My skin feels alive.” This is usually the peak of patient satisfaction.

🔹 Months 4–6 — Structural Stabilization and Result Maintenance

From the fourth month, cellular regeneration enters the “stabilization” phase. New collagen aligns in an organized manner, newly formed capillaries stabilize, and initial mild inflammation disappears. The skin reaches a balanced, healthy, and stable state. With proper care (sunscreen, antioxidants, adequate sleep), this state can last up to two years.

🔹 After 6 Months — Skin at Its Best

Results reach their maximum during this time. The skin becomes thicker and more translucent, subcutaneous tissue regains natural volume, and the face achieves a gentle radiance. Due to the continued activity of some stem cells, the repair process continues, albeit more slowly. Maintenance sessions like hydrating mesotherapy or mild RF can be performed if needed.

🔹 Year 1–2 — Long-Term Stability Phase

A standout feature of SVF is its long-lasting effect. Clinical studies show regenerative effects maintained up to 24 months post-injection. Lifestyle, nutrition, sun exposure, and sleep quality significantly influence durability. Physicians may recommend an annual booster injection (Booster SVF or Nano-Fat) to keep collagen regeneration active.

Time Frame	Visible Skin Changes	Dominant Cellular Activity
Weeks 1–2	Redness, mild swelling, gradual skin calming	Stem cell activation and initiation of controlled inflammation
Weeks 3–4	Increased softness and radiance, more even color	Neovascularization and beginning of collagen synthesis
Months 2–3	Improved firmness, reduced fine lines, more vibrant appearance	Active collagen and elastin synthesis
Months 4–6	Firmer, more translucent skin; results stabilized	Immune regulation, stable tissue regeneration
Months 7–24	Youthful, smooth, healthy skin with natural radiance	Maintaining cellular metabolism and gradual regeneration

For real patient examples and results after 6 months, visit Dr. Fatouhi’s Rejuvenation Services page.

🔬 Combining SVF with Other Rejuvenation Methods — Therapeutic Coordination for Optimal Results

One of the major advantages of SVF treatment is that it can be combined with other skin rejuvenation and regeneration methods. SVF establishes the biological and reparative foundation of the skin, while other treatments can enhance its effect. This section shows which combinations are safe, scientific, and effective, and when they should be performed for optimal synergy.

🌿 SVF + Nano-Fat

Nano-fat and SVF are both extracted from body fat but serve different purposes. Nano-Fat is primarily for subtle subcutaneous volume restoration, whereas SVF focuses on improving cellular function and skin quality. Combining these methods, especially on the face, neck, and back of the hands, increases skin firmness and radiance with very natural volume. At Dr. Fatouhi’s clinic, nano-fat is often injected deeper and SVF more superficially to achieve a dual effect of “reconstruction + volume.”

💧 Mesotherapy and Meso-Gun Combination

Hydrating or antioxidant mesotherapy complements SVF perfectly. While SVF activates regeneration at the cellular level, mesotherapy provides vitamins, hyaluronic acid, and reparative peptides to create an ideal environment for new cell growth. This combination enhances skin radiance, clarity, and hydration, especially effective for dry, tired, or stressed skin.

⚡ Radio Frequency (RF) Combination

RF (Radio Frequency) technology generates controlled heat in the mid-dermal layer, contracting existing collagen and activating fibroblasts. When combined with SVF, the regenerative effect multiplies: newly activated cells grow faster in the metabolic RF environment. Non-invasive RF (fractional or superficial microneedling RF) is typically allowed from the third month and increases skin firmness.

💎 Laser and Mild Peel Combinations

Superficial resurfacing lasers (e.g., Fraxel, CO₂ Lite, Nd:YAG) can complement SVF by stimulating the epidermal layer. This allows simultaneous surface and deep rejuvenation. Mild chemical peels with lactic or salicylic acid are feasible after the third month to smooth surface skin texture.

🌸 Hair Treatments — PRP or Mesotherapy for Hair

For hair loss, combining SVF with PRP (platelet-rich plasma) is one of the most effective follicle regeneration methods. PRP provides a growth factor-rich environment, while SVF delivers stem cells necessary for follicle repair. Performing both in one session or with a 4-week interval can double hair density and thickness.

💫 Botox or Light Fillers Combination

To achieve a more complete result, SVF injections can be combined with light fillers or Botox. SVF improves tissue and texture, while Botox moderates dynamic wrinkles, and fillers restore subtle volume. This combination is especially suitable for thin faces or delicate skin and appears completely natural.

Complementary Method	Suggested Timing from SVF	Treatment Goal
Nano-Fat	Same session or 4–6 weeks later	Volume restoration and firmness
Mesotherapy	From second month onward	Enhanced hydration and radiance
RF or Microneedling	8–12 weeks later	Increased firmness and natural lift
PRP or Hair Mesotherapy	Same session or 4 weeks later	Hair follicle stimulation
Botox / Light Filler	4–6 weeks later	Facial harmony and natural youth

For a personalized skin combination program, visit Dr. Fatouhi’s Rejuvenation Services.

💬 Patient Experience — Where Science, Beauty, and Trust Converge

No description conveys the impact of SVF better than real patient experiences. At Dr. Fatouhi’s clinic, hundreds of patients aged 25–65 have undergone SVF for skin reconstruction, wrinkle reduction, texture improvement, or female genital rejuvenation. What is common among them is the feeling of “natural results” — visible improvement that doesn’t shout.Many patients report no longer needing repeated fillers or Botox because their skin quality naturally improved. SVF is not just a cosmetic procedure; it is a restoration of the body’s natural function.

👩‍⚕️ Physician Insight — Dr. Samaneh Fatouhi

Dr. Fatouhi on the philosophy of SVF:

“True rejuvenation means restoring the skin’s natural ability to repair itself. We help the body remember how to be healthy and beautiful. Nothing is more beautiful than your body’s own cells.”

🔔 Why Dr. Fatouhi’s Clinic is the First Choice for SVF

• Performed by an experienced dermatologist specializing in regenerative medicine
• Use of closed systems for high cell purity and safety
• Customized pre- and post-care protocols for each patient
• Intelligent combination of SVF with complementary treatments based on skin type
• Natural results without artificial or puffy appearance

🌺Final Words — Inner Regeneration, Natural Radiance

SVF is where cellular science meets aesthetic art. Instead of hiding aging signs, it teaches the body to rejuvenate itself. When your own living cells are returned to the skin, the outcome goes beyond beauty — it is a return to true health. A serene face, radiant skin, and inner confidence shine through.